Esquel/Choila Area/Argentina (www.esqueloutfitters.com)
There is no question that the team of guides and staff employed by Esquel Outfitters is one of the best I have seen in Patagonia. 
They are a professional organization that is 100% focused on insuring the well being of its guests. They fish a huge cross section of rivers and lakes over a large geographic area, so where you fish and stay will depend on your interests as an angler. Choices are varied and include the Rio Pico/Corcovado region, the Esquel Region, and the rivers around Cholila and Los Alerces National Park. You could spend three (3) weeks fishing with Esquel Outfitters and not repeat a river or lake the whole time. In addition to the excellent lodges utilized, you will also have the opportunity to do some first class camping. Some of the rivers you might fish include the Rivadavia, Nant Y Fall, Rio Frey, Carrileufu, Futalafu (Rio Grande), Chubut, Guiljiana, Arroyo Pescado, Corcovado and Rio Pico. The lakes and rivers around Los Alerces National Park near Cholila provide stunning scenery you are not likely to forget. The trout will range in size for 12-24 inches, depending on where you are fishing and the land locked salmon in the Carrileufu are an added bonus and a great deal of fun if you are lucky enough to catch one. All the lodges are well maintained, fully staffed and provide superb meals and top shelf wines. Estancia El Vira is a massive working ranch with more than 20 miles of exclusive access to the Guiljiana river which is known for it superb dry fly fishing.
Coyhaique Area/Chile (www.www.cincorios.cl)
Within one hours drive of the lodge there are dozens of rivers that are loaded with wild brown and rainbow trout that are eager to take a fly. 
The name Coyhaique literally means "meeting of rivers," in the native tongue. Over the last ten years I have seen the fishing pressure increase significantly but Cinco Rios has access to areas that are seldom visited by other anglers. They, for example, have jet boats strategically placed on remote rivers which allows them to motor into areas others can not. They also have agreements with landowners that allow the guides access through private property. This access makes a huge difference in terms of the quality of the fishing experience. I am still learning about new areas from the guides that I did not know existed. Some of the rivers on the menue include the Paloma, Simpson, Manihuales, Nireguao, Mogote, and many, many more. For the angler that wants to fish a different river everyday, using different techniques, this is one of the best places in all Patagonia. As an added bonus, the lake fishing is outstanding. Most of the clients that I have traveled to Patagonia with for the first time will tell me that they want to fish rivers and that lake fishing is of little interest. Fishing the lakes around Coyhaique to large cruising browns that slowly rise up out of 10 feet of gin clear water to inhale a size 4 fat albert beetle will most likely change your mind in a hurry. It can be site fishing at its best!
Rio Baker Area/Chile
The Rio Baker is a huge river that supports an incredible population of rainbow trout that average 16-17 inches with many in the 19-21 inch range. 
Mostly they are not difficult to catch and can be seen feeding on dries and caddis pupa in huge back eddies. Some of the larger fish provide challenging dry fly fishing in quiet waters near shore. There are also large gravel bars with productive down stream riffles where a good nymph fisherman can have a field day. The lodge in this area is gorgeous and sits on one of the largest lakes in South America. The fishing in front of the lodge is excellent and there are both trophy browns and rainbows to be caught in a large channel that runs for a short distance between two lakes. In addition to the Rio Baker, and the fishing in front of the lodge, there is a technical river that fishes much like a spring creek where sight fishing is the name of the game. The fishing can be tough here but the rewards are great and it supports an excellent population of huge browns and rainbows that range in size from 4-10 pounds. Keep in mind it is very possible to combine fishing in this area with the Coyhaique area by means of a 4 hour drive.
Rio Paloma/Chile (www.palomariverlodge.com)
To get to Paloma River Lodge you fly into Balmaceda and will be picked up by a representative of the lodge.
The lodge is not fancy but very comfortable, providing each angler with their own private bed and bath. There is not a better value in Patagonia than PRL and the scenery in this area some of the most beautiful in all of Chile. The Paloma and surrounding lakes provide great dry fly fishing to large browns and rainbows. Head guide, Fernando (Fenya), is an extremely capable and charming guide who knows his fishery well. Known for its terrestrial fishing, the Paloma is a gin clear river with a fantastic population of good sized brown and rainbow trout. The Paloma has every kind of water type you could ask for. There are canyon sections, long runs, pocket water, undercut banks, structure, and numerous channels and braids where you can comfortable wade and sight fish. There are excellent fishing choices here with several very productive small streams, a spring creek, numerous lakes and river mouths. Aside from the fishing, you will get a feeling of remoteness and are not likely to see other fisherman. Fishing with PRL is somehow more "authentic." The meals prepared by the lodge chef are magnificent and the deserts delicious. Paloma River Lodge caters to small groups of 4 to 6 anglers so you will get superior service in an intimate setting.
Rio Pico Area / Argentina(www.laspampaslodge.com)
Fishing the Rio Pico area out of Las Pampas Lodge is a special treat. 
The fishing options are varied and anglers will have the choice of fishing for trophy trout (4-12lbs) in one of several nearby lakes or fishing gin clear freestone rivers or technical spring creeks. LPL has private access to an area they call "Africa" because it looks like the plains of Africa when you drive in on a rustic dirt road. This is an amazing fishery with an array of small streams and channels that seem to enter and exit a marshy area in every direction. The only way to understand this area is to see it and fish it for yourself. It is incredible! Sight fishing to browns and rainbows from 16-20 inches is common and they love to take dries. Aside from the great fishing out of Las Pampas Lodge, you will find the food nothing short of gourmet, the rooms comfortable and the overall vibe at the lodge welcoming and fun.
Lago Yelcho Area/Chile
www.chucaolodge.cl
The operation I have chosen to service this magnificent area has two first class lodges that are strategically located, giving you a variety of fishing options and diversity. 
The owner of the lodge is Gonzalo Cortes who wrote the book, "Fly Fishing in Chilean Patagonia." The fact that he has chosen this area to base his two lodges is significant. The first lodge is on the boca of the Rio Yelcho which is the perfect place to start any float trip on the Yelcho River and gives you immediate access to the unbelievable dry fly fishing on Lago Yelcho. The second lodge is on Lago Rosselot and right next to the beautiful and productive Palena and Figueroa rivers. There is no way you can even come close to fishing all these waters in a week but it is nice to know that you have options. Gonzalo has several kinds of specially designed boats for fishing the lakes and rivers of this region. For the angler that enjoys targeting large fish (4-15 pounds) with streamers this is a great place for that pursuit. There are also places where dry fly enthusiasts can sight fish to pods of rainbows in the 16-24 inch range that are sipping insects all day long in some of the rivers back eddies. Aside from the fantastic fishing, the setting could not be more breathtaking and you will be surrounded by virgin forests, glaciers, and volcanoes. The food, service and hospitality are in keeping with most of the lodges in Patagonia....it is outstanding!
Bariloche & Junin de los Andes Area/Argentina www.outfitterspatagonia.com & www.chimelodge.com
Bariloche is the starting point for most fishing trips to Junin and Esquel and has several good rivers to fish with in close proximity to this picturesque ski town. Rivers like the Limay and Manso, as well as several lakes are great places to begin any fishing adventure. The Junin area has great fishing diversity and an abundance of rivers to choose from. 
Rivers like the Collon Cura, Alumine, Chimehuin, Caleufu, and Malleo will be on the menu, and there is a variety of places to stay. We work with two different operations to service this magnificent area, and where you fish and stay will depend on your interests and budget. There are several high end lodges with private river access such as San Huberto Lodge on the Malleo (www.sanhubertolodge.com.ar), Tipiliuke Lodge on the Chimehun (www.tipiliuke.com), and Estancia Quemquemtreu on the Collon Cura (www.quemquemtreu.com). All of these lodges provide the utmost in hospitality, accommodations, cuisine and fine wine. Any combination of lodges, small hotels, and camping can be arranged on a given week. Martin Caranza's brand new (Chime Lodge) , on the banks of the upper Chimehuin, is another great option. From this lodge you can fish all the rivers mentioned above and return home each day to a great meal and comfortable bed. For more hard core anglers who want to put in long days with some of the area's most talented, younger guides, I recommend Martin Freedman's Outfitters Patagonia (www.outfitterspatagonia.com). His operation is top notch in all respects and if you like to float and camp there is no better option. Camping allows you to fish remote areas and put in longer fishing days. Regardless of where you stay you will find the Junin area reminiscent of the American West. The weather is more reliable here and receives less rainfall than other parts of Patagonia and the dry fly fishing is superb.
